THBS4 Gene Summary [Human]
The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. It is involved in local signaling in the developing and adult nervous system, and it contributes to spinal sensitization and neuropathic pain states. This gene is activated during the stromal response to invasive breast cancer. It may also play a role in inflammatory responses in Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Details
| Type | Processed Transcript |
| Official Symbol | THBS4 |
| Official Name | thrombospondin 4 [Source:HGNC Symbol;Acc:HGNC:11788] |
| Ensembl ID | ENSG00000113296 |
| Bio databases IDs | |
| Aliases | thrombospondin 4 |
| Synonyms | thrombospondin 4, TSP-4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human THBS4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LamG
- calcium ion binding
- coiled-coil domain
- protein binding
- identical protein binding
- fibronectin binding
- EGF_CA
- thrombospondin type 3 repeat
- Thrombospondin C-terminal region
- Coiled coil region of thrombospondin
- laminin binding
- integrin binding
- collagen binding
- EGF domain
- heparin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- allodynia
- thermal hyperalgesia
- hypertrophic scarring
- osteogenesis imperfecta type III
- prostate cancer
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- adult T-cell leukemia/lymphoma
role in cell
- expression in
- adhesion
- density
- chemotaxis
- activation
- proliferation
- growth
- phosphorylation in
- migration
- killing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- sarcoplasmic reticulum
- Endoplasmic Reticulum
- granules
- neuromuscular junctions
- extracellular matrix
- plasma
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human THBS4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- signal transduction
- positive regulation of neutrophil chemotaxis
- response to unfolded protein
- tissue remodeling
- positive regulation of cell division
- myoblast migration
- behavioral response to pain
- regulation of tissue remodeling
- positive regulation of endothelial cell proliferation
- positive regulation of peptidyl-tyrosine phosphorylation
- response to endoplasmic reticulum stress
- endothelial cell-cell adhesion
Cellular Component
Where in the cell the gene product is active
- extracellular space
- basement membrane
- extracellular vesicular exosome
- sarcoplasmic reticulum
- endoplasmic reticulum
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- calcium ion binding
- heparin binding
- integrin binding