GRK7 Gene Summary [Human]
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GRK7 |
| Official Name | G protein-coupled receptor kinase 7 [Source:HGNC Symbol;Acc:HGNC:17031] |
| Ensembl ID | ENSG00000114124 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor kinase 7 |
| Synonyms | GPRK7, G protein-coupled receptor kinase 7 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GRK7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Regulator of G protein signaling domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- rhodopsin kinase
- Regulator of G protein signaling (RGS) domain superfamily
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the GRK7 gene in human plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GRK7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- protein autophosphorylation
- visual perception
- protein phosphorylation
- regulation of signal transduction
- regulation of rhodopsin mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- rhodopsin kinase activity
- protein binding