AADAC Gene Summary [Human]
Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | AADAC |
| Official Name | arylacetamide deacetylase [Source:HGNC Symbol;Acc:HGNC:17] |
| Ensembl ID | ENSG00000114771 |
| Bio databases IDs | |
| Aliases | arylacetamide deacetylase |
| Synonyms | 5033417E09Rik, Aada, arylacetamide deacetylase, CES5A1, DAC |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AADAC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carboxylic ester hydrolase
- alpha/beta hydrolase fold
- alpha/beta hydrolases
- lipase
- serine hydrolase
- enzyme
- protein binding
- deacetylase
- triacylglycerol lipase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- placenta accreta spectrum
- diabetes mellitus
- adenoma formation
- aldosterone producing adrenocortical adenoma
role in cell
- expression in
- accumulation in
- proliferation
- ferroptosis
- peroxidation in
- oxidation in
- colonization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AADAC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid metabolic process
- xenobiotic metabolic process
- positive regulation of triglyceride catabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- serine hydrolase activity
- protein binding
- catalytic activity
- triglyceride lipase activity
- lipase activity
- deacetylase activity