CYTIP Gene Summary [Human]
The protein encoded by this gene contains 2 leucine zipper domains and a putative C-terminal nuclear targeting signal, but does not have any hydrophobic regions. This protein is expressed weakly in resting NK and T cells. The encoded protein modulates the activation of ARF genes by CYTH1. This protein interacts with CYTH1 and SNX27 proteins and may act to sequester CYTH1 protein in the cytoplasm.[provided by RefSeq, Aug 2008]
Details
| Type | Protein Coding |
| Official Symbol | CYTIP |
| Official Name | cytohesin 1 interacting protein [Source:HGNC Symbol;Acc:HGNC:9506] |
| Ensembl ID | ENSG00000115165 |
| Bio databases IDs | |
| Aliases | cytohesin 1 interacting protein, cytohesin binding protein HE, cytohesin binder and regulator |
| Synonyms | A130053M09RIK, AI462064, B3-1, CASP, Cbp, CYBR, CYTHIP, cytohesin 1 interacting protein, Cytohesin binding, HE, PSCDBP, tamalin |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CYTIP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- canonical PDZ domain
- coiled-coil domain
- protein binding
- PDZ domain
- cpPDZ_RseP_YlbL-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- tumorigenesis
- androgenic alopecia
- non-insulin-dependent diabetes mellitus
- hypoplasia
- allergic contact dermatitis
- ulcerative colitis
- peripheral arterial disease
- prostate cancer
role in cell
- proliferation
- quantity
- migration
- adhesion
- number
- abnormal morphology
- production in
- emigration
- extravasation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- cell cortex
- endosomes
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CYTIP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell adhesion
Cellular Component
Where in the cell the gene product is active
- early endosome
- cytoplasm
- cell cortex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding