STK25 Gene Summary [Human]
This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
Details
| Type | Protein Coding |
| Official Symbol | STK25 |
| Official Name | serine/threonine kinase 25 [Source:HGNC Symbol;Acc:HGNC:11404] |
| Ensembl ID | ENSG00000115694 |
| Bio databases IDs | |
| Aliases | serine/threonine kinase 25 |
| Synonyms | 1500019J11RIK, AI042849, AU018434, MST5, serine/threonine kinase 25, serine/threonine kinase 25 (yeast), SOK1, STE20 Kinase 5, Ste20-like, YSK1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STK25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- zDHHC ankyrin repeat binding domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- protein homodimerization
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypothyroidism
- brachydactyly mental retardation syndrome
- hepatic fibrosis
- hepatocellular damage
- liver damage
- nonalcoholic steatohepatitis
- fibrosis
- uterine leiomyoma
- leiomyomatosis
- hepatic steatosis
role in cell
- cell death
- apoptosis
- phosphorylation in
- formation
- formation in
- damage in
- migration
- invasion
- response by
- localization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- cytosol
- Golgi membrane
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STK25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Golgi reassembly
- signal transduction
- establishment or maintenance of cell polarity
- protein autophosphorylation
- protein phosphorylation
- response to oxidative stress
- positive regulation of axonogenesis
- establishment of Golgi localization
- axonogenesis
- cellular response to oxidative stress
- positive regulation of stress-activated MAPK cascade
- Golgi localization
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein homodimerization activity
- metal ion binding
- protein kinase activity
- protein serine/threonine kinase activity