Stk25 Gene Summary [Rat]
Predicted to enable protein homodimerization activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including establishment of Golgi localization; intrinsic apoptotic signaling pathway in response to hydrogen peroxide; and positive regulation of stress-activated MAPK cascade. Predicted to act upstream of or within several processes, including Golgi localization; positive regulation of axonogenesis; and protein phosphorylation. Located in Golgi membrane. Orthologous to human STK25 (serine/threonine kinase 25). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stk25 |
| Official Name | serine/threonine kinase 25 [Source:RGD Symbol;Acc:727809] |
| Ensembl ID | ENSRNOG00000018181 |
| Bio databases IDs | |
| Aliases | serine/threonine kinase 25 |
| Synonyms | 1500019J11RIK, AI042849, AU018434, MST5, serine/threonine kinase 25, serine/threonine kinase 25 (yeast), SOK1, STE20 Kinase 5, Ste20-like, YSK1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Stk25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- zDHHC ankyrin repeat binding domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- protein homodimerization
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypothyroidism
- brachydactyly mental retardation syndrome
- hepatic fibrosis
- hepatocellular damage
- liver damage
- nonalcoholic steatohepatitis
- fibrosis
- uterine leiomyoma
- leiomyomatosis
- hepatic steatosis
role in cell
- cell death
- apoptosis
- phosphorylation in
- formation
- formation in
- damage in
- migration
- invasion
- response by
- localization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- cytosol
- Golgi membrane
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Stk25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Golgi reassembly
- signal transduction
- establishment or maintenance of cell polarity
- protein autophosphorylation
- protein phosphorylation
- response to oxidative stress
- positive regulation of axonogenesis
- establishment of Golgi localization
- axonogenesis
- cellular response to oxidative stress
- positive regulation of stress-activated MAPK cascade
- Golgi localization
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein homodimerization activity
- metal ion binding
- protein kinase activity
- protein serine/threonine kinase activity