RNF19B Gene Summary [Human]
This gene encodes a multi-pass membrane protein containing two RING-type and one IBR-type zinc finger motifs. The encoded protin is an E3 ubiquitin-protein ligase that plays a role in the cytotoxic effects of natural killer (NK) cells. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes X and Y in a possible pseudoautosomal region. [provided by RefSeq, Jul 2014]
Details
| Type | Protein Coding |
| Official Symbol | RNF19B |
| Official Name | ring finger protein 19B [Source:HGNC Symbol;Acc:HGNC:26886] |
| Ensembl ID | ENSG00000116514 |
| Bio databases IDs | |
| Aliases | ring finger protein 19B, natural killer lytic-associated molecule |
| Synonyms | 4930534K13RIK, 4930555L03Rik, FLJ90005, IBRDC3, NKLAM, ring finger protein 19B, Rn19, W27419 31a10 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF19B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IBR domain, a half RING-finger domain
- In Between Ring fingers
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- BRcat_Rcat_RBR
- ubiquitin binding
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
regulates
role in cell
- cytolysis by
- BI-2536 sensitivity
- JG-231 sensitivity
- TAK-901 sensitivity
- thenoyltrifluoroacetone sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- lysosome
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF19B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
- adaptive immune response
- natural killer cell mediated cytotoxicity
- protein autoubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytolytic granule
- ubiquitin ligase complex
- cytoplasm
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- ubiquitin conjugating enzyme binding
- protein binding
- ubiquitin binding