NEK9 Gene Summary [Human]
This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein is activated in mitosis and, in turn, activates other family members during mitosis. This protein also mediates cellular processes that are essential for interphase progression. [provided by RefSeq, Jul 2016]
Details
| Type | Protein Coding |
| Official Symbol | NEK9 |
| Official Name | NIMA related kinase 9 [Source:HGNC Symbol;Acc:HGNC:18591] |
| Ensembl ID | ENSG00000119638 |
| Bio databases IDs | |
| Aliases | NIMA related kinase 9 |
| Synonyms | APUG, C130021H08Rik, KIAA1995, LCCS10, NC, NERCC, NERCC1, Nercc1 kinase, NIMA (never in mitosis gene a)-related expressed kinase 9, NIMA-related kinase 9 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NEK9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of chromosome condensation (RCC1) repeat
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- kinase
- protein kinase activator
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nevus comedonicus
- hereditary disorder
- arthrogryposis, Perthes disease, and upward gaze palsy
- lethal congenital contracture syndrome type 10
- Hutchinson-Gilford progeria syndrome
- epidermal inclusion cyst
- esophageal adenocarcinoma
- esophageal carcinoma formation
- Goldberg-Shprintzen megacolon syndrome
- productive infection by HIV-1
role in cell
- formation
- G1 phase
- segregation
- S phase
- replication in
- prometaphase
- alignment
- mitosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NEK9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- mitotic cell cycle
- regulation of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- ATP binding
- protein binding
- metal ion binding
- protein kinase activator activity
- protein serine/threonine kinase activity