NID1 Gene Summary [Human]
This gene encodes a member of the nidogen family of basement membrane glycoproteins. The protein interacts with several other components of basement membranes, and may play a role in cell interactions with the extracellular matrix. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NID1 |
| Official Name | nidogen 1 [Source:HGNC Symbol;Acc:HGNC:7821] |
| Ensembl ID | ENSG00000116962 |
| Bio databases IDs | |
| Aliases | nidogen 1 |
| Synonyms | A630025O17, ENTACTIN, entactin-1, NID, NIDOGEN, nidogen-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NID1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nidogen-like
- Complement Clr-like EGF-like
- extracellular matrix binding
- extracellular matrix structural constituent
- nidG2
- protein binding
- Low-density lipoprotein receptor repeat class B
- EGF_CA
- binding protein
- laminin binding
- TY
- collagen binding
- EGF domain
- Low-density lipoprotein-receptor YWTD domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cytomegalovirus infection
- seizures
- ulcerative colitis
- diverticulitis
- nevus
- epithelial thyroid cancer
- colorectal cancer
- early missed abortion
- laser induced choroidal neovascularization
role in cell
- migration
- formation
- adhesion
- development
- organization
- differentiation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell periphery
- basal membrane
- extracellular matrix
- basal lamina
- exosomes
- basement membrane
- glomerular basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NID1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- glomerular basement membrane development
- basement membrane organization
- canonical Wnt receptor signaling pathway
- positive regulation of cell-substrate adhesion
- positive regulation of cell adhesion
- positive regulation of integrin-mediated signaling pathway
- positive regulation of muscle cell differentiation
Cellular Component
Where in the cell the gene product is active
- basement membrane
- extracellular vesicular exosome
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- Wnt-activated receptor activity
- proteoglycan binding
- collagen binding
- calcium ion binding
- laminin-1 binding
- Wnt-protein binding
- extracellular matrix structural constituent
- laminin binding