Nid1 Gene Summary [Mouse]
Enables collagen binding activity and laminin-1 binding activity. Acts upstream of or within cell-matrix adhesion; glomerular basement membrane development; and positive regulation of cell-substrate adhesion. Located in basement membrane. Is expressed in several structures, including alimentary system; blastocyst; eye; genitourinary system; and nervous system. Orthologous to human NID1 (nidogen 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nid1 |
| Official Name | nidogen 1 [Source:MGI Symbol;Acc:MGI:97342] |
| Ensembl ID | ENSMUSG00000005397 |
| Bio databases IDs | |
| Aliases | nidogen 1 |
| Synonyms | A630025O17, ENTACTIN, entactin-1, NID, NIDOGEN, nidogen-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nid1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nidogen-like
- Complement Clr-like EGF-like
- extracellular matrix binding
- extracellular matrix structural constituent
- nidG2
- protein binding
- Low-density lipoprotein receptor repeat class B
- EGF_CA
- binding protein
- laminin binding
- TY
- collagen binding
- EGF domain
- Low-density lipoprotein-receptor YWTD domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cytomegalovirus infection
- seizures
- ulcerative colitis
- diverticulitis
- nevus
- epithelial thyroid cancer
- colorectal cancer
- early missed abortion
- laser induced choroidal neovascularization
role in cell
- migration
- formation
- adhesion
- development
- organization
- differentiation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell periphery
- basal membrane
- extracellular matrix
- basal lamina
- exosomes
- basement membrane
- glomerular basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nid1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- glomerular basement membrane development
- basement membrane organization
- canonical Wnt receptor signaling pathway
- positive regulation of cell-substrate adhesion
- positive regulation of cell adhesion
- positive regulation of integrin-mediated signaling pathway
- positive regulation of muscle cell differentiation
Cellular Component
Where in the cell the gene product is active
- basement membrane
- extracellular vesicular exosome
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- Wnt-activated receptor activity
- proteoglycan binding
- collagen binding
- calcium ion binding
- laminin-1 binding
- Wnt-protein binding
- extracellular matrix structural constituent
- laminin binding