DGKA Gene Summary [Human]
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Several transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Apr 2017]
Details
| Type | Protein Coding |
| Official Symbol | DGKA |
| Official Name | diacylglycerol kinase alpha [Source:HGNC Symbol;Acc:HGNC:2849] |
| Ensembl ID | ENSG00000065357 |
| Bio databases IDs | |
| Aliases | diacylglycerol kinase alpha |
| Synonyms | Alpha diacylglycerol kinase, DAGK, DAGK1, Dagk α, DGK-alpha, DGK-α, diacylglycerol kinase alpha, diacylglycerol kinase, alpha, diacylglycerol kinase α, diacylglycerol kinase, α, α diacylglycerol kinase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DGKA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- EF-hand, calcium binding motif
- lipid binding
- diacylglycerol kinase
- EF-hand domain pair
- EFh
- Diacylglycerol kinase catalytic domain (presumed)
- kinase
- kinase domain
- Diacylglycerol kinase N-terminus
- EF hand
- Diacylglycerol kinase accessory domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- Diacylglycerol kinase catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- acute myeloid leukemia
- metastasis
- organismal death
- esophageal squamous cell cancer
- esophageal squamous cell carcinoma
- localized aggressive periodontitis
- colon cancer
role in cell
- phosphorylation in
- expression in
- activation in
- survival
- invasion by
- proliferation
- production in
- migration
- growth
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- Plasma Membrane
- cytosol
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DGKA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycerolipid metabolic process
- protein kinase C-activating G-protein coupled receptor signaling pathway
- platelet activation
- intracellular signal transduction
- phosphatidic acid biosynthetic process
- lipid phosphorylation
- diacylglycerol metabolic process
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calcium ion binding
- lipid binding
- diacylglycerol kinase activity
- phospholipid binding
- alkylglycerol kinase activity
- kinase activity