TSPAN1 Gene Summary [Human]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]

Details

Type
Processed Transcript
Official Symbol
TSPAN1
Official Name
tetraspanin 1 [Source:HGNC Symbol;Acc:HGNC:20657]
Ensembl ID
ENSG00000117472
Bio databases IDs NCBI: 10103 Ensembl: ENSG00000117472
Aliases tetraspanin 1
Synonyms 9030418M05Rik, NET1, Tetraspanin 1, TETRASPANIN TM4-C, Tetraspan NET-1, TM4C, TM4SF
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TSPAN1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • tetraspanin_LEL
  • protein binding

Pathways

Biological processes and signaling networks where the TSPAN1 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • endometriosis
  • renal cancer
regulated by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cell junction
  • intracellular membrane-bounded organelle
  • perinuclear region
  • cellular membrane
  • Plasma Membrane
  • vesicles
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human TSPAN1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • protein stabilization

Cellular Component

Where in the cell the gene product is active
  • extracellular vesicular exosome
  • perinuclear region of cytoplasm
  • cytoplasm
  • intracellular membrane-bounded organelle
  • membrane
  • vesicle
  • cell junction
  • plasma membrane
  • lysosomal membrane
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.