IRAG2 Gene Summary [Human]
The protein encode dby this gene is expressed in a developmentally regulated manner in lymphoid cell lines and tissues. The protein is localized to the cytoplasmic face of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IRAG2 |
| Official Name | inositol 1,4,5-triphosphate receptor associated 2 [Source:HGNC Symbol;Acc:HGNC:6690] |
| Ensembl ID | ENSG00000118308 |
| Bio databases IDs | |
| Aliases | inositol 1,4,5-triphosphate receptor associated 2 |
| Synonyms | D6Int3, D6Int4, D6Int5, D6Int7, D6Int8, inositol 1,4,5-triphosphate receptor associated 2, JAW1, LOC645177, LRMP, RGD1562062 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IRAG2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Coiled-coil region of CCDC155 or KASH
- microtubule binding
- EF-hand domain
- protein binding
- MRVI1 protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- Endoplasmic Reticulum
- secretory granule membrane
- endoplasmic reticulum membrane
- lysosome membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IRAG2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle fusion
- vesicle targeting
- single fertilization
- nucleus organization
- immune system process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear envelope
- centrosome
- membrane
- spindle pole
- chromosome
- azurophil granule membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- microtubule binding