HMGN3 Gene Summary [Human]
The protein encoded by this gene binds thyroid hormone receptor beta in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is a related pseudogene on chromosome 1. [provided by RefSeq, Jan 2016]
Details
| Type | Protein Coding |
| Official Symbol | HMGN3 |
| Official Name | high mobility group nucleosomal binding domain 3 [Source:HGNC Symbol;Acc:HGNC:12312] |
| Ensembl ID | ENSG00000118418 |
| Bio databases IDs | |
| Aliases | high mobility group nucleosomal binding domain 3 |
| Synonyms | 1110002A15Rik, 6330514M13RIK, high mobility group nucleosomal binding domain 3, PNAS-24, PNAS-25, TRIP7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HMGN3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HMG14 and HMG17
- domain in high mobilty group proteins HMG14 and HMG 17
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic kidney disease
- hypoalgesia
- weight loss
role in cell
- transcription in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HMGN3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- nucleosomal DNA binding
- chromatin binding
- thyroid hormone receptor binding