GTF3C3 Gene Summary [Human]
The protein encoded by this gene is part of the TFIIIC2 complex, which binds to the promoters of small nuclear and cytoplasmic RNA genes in order to recruit RNA polymerase III. The TFIIIC2 complex is composed of six subunits. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | GTF3C3 |
| Official Name | general transcription factor IIIC subunit 3 [Source:HGNC Symbol;Acc:HGNC:4666] |
| Ensembl ID | ENSG00000119041 |
| Bio databases IDs | |
| Aliases | general transcription factor IIIC subunit 3 |
| Synonyms | AL022818, general transcription factor IIIC, polypeptide 3, general transcription factor IIIC subunit 3, TF3C-gamma, TF3C-γ, TFIIIC102, TFiiiC2-102, TFIIICgamma |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GTF3C3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Tetratricopeptide repeats
- protein binding
- tetratricopeptide repeat
Pathways
Biological processes and signaling networks where the GTF3C3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- Cytoplasm
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GTF3C3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase III promoter
- 5S class rRNA transcription from RNA polymerase III type 1 promoter
- tRNA transcription from RNA polymerase III promoter
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- transcription factor TFIIIC complex
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- core RNA polymerase III binding transcription factor activity