DEDD2 Gene Summary [Human]
This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Details
| Type | Protein Coding |
| Official Symbol | DEDD2 |
| Official Name | death effector domain containing 2 [Source:HGNC Symbol;Acc:HGNC:24450] |
| Ensembl ID | ENSG00000160570 |
| Bio databases IDs | |
| Aliases | death effector domain containing 2 |
| Synonyms | 2410050E11Rik, death effector domain containing 2, death effector domain-containing DNA binding protein 2, FLAME-3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DEDD2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death effector domain
- nuclear localization sequence
- protein binding
- Death Domain Superfamily of protein-protein interaction domains
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DEDD2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular homeostasis
- negative regulation of transcription, DNA-dependent
- apoptotic nuclear change
- rRNA catabolic process
- positive regulation of extrinsic apoptotic signaling pathway
- RNA processing
- induction of apoptosis via death domain receptors
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- receptor signaling complex scaffold activity