Slirp Gene Summary [Mouse]
Predicted to enable mRNA 3'-UTR binding activity and poly(G) binding activity. Acts upstream of or within several processes, including flagellated sperm motility; negative regulation of mitochondrial RNA catabolic process; and spermatid development. Located in several cellular components, including acrosomal vesicle; perinuclear region of cytoplasm; and sperm flagellum. Part of ribonucleoprotein complex. Is expressed in ovary and seminiferous cord. Orthologous to human SLIRP (SRA stem-loop interacting RNA binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slirp |
| Official Name | SRA stem-loop interacting RNA binding protein [Source:MGI Symbol;Acc:MGI:1916394] |
| Ensembl ID | ENSMUSG00000021040 |
| Bio databases IDs | |
| Aliases | SRA stem-loop interacting RNA binding protein |
| Synonyms | 1810035L17Rik, C14orf156, DC50, LOC681987, PD04872, SRA stem-loop interacting RNA binding protein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slirp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- Huntington disease
- mitochondrial encephalomyopathy
role in cell
- development
- motility
- abnormal morphology
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- Mitochondria
- mitochondrial matrix
- sperm tail
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slirp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sperm motility
- spermatid development
- negative regulation of mitochondrial RNA catabolic process
- single fertilization
- mitochondrion organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- mitochondrial matrix
- acrosomal vesicle
- mitochondrion
- sperm flagellum
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding