SIMC1 Gene Summary [Human]
Enables SUMO polymer binding activity and peptidase inhibitor activity. Predicted to be involved in negative regulation of peptidase activity. Located in sarcomere. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SIMC1 |
| Official Name | SUMO interacting motifs containing 1 [Source:HGNC Symbol;Acc:HGNC:24779] |
| Ensembl ID | ENSG00000170085 |
| Bio databases IDs | |
| Aliases | SUMO interacting motifs containing 1, oocyte maturation associated 1, platform element for inhibition of autolytic degradation |
| Synonyms | 4732471D19Rik, C5orf25, OOMA1, PLEIAD, SUMO-interacting motifs containing 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SIMC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protease inhibitor
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- sarcomere
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SIMC1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- PML body
- cytoplasm
- sarcomere
Molecular Function
What the gene product does at the molecular level
- peptidase inhibitor activity
- protein binding
- SUMO polymer binding