TASL Gene Summary [Human]
Involved in positive regulation of innate immune response; positive regulation of toll-like receptor signaling pathway; and regulation of lysosomal lumen pH. Located in endolysosome membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TASL |
| Official Name | TLR adaptor interacting with endolysosomal SLC15A4 [Source:HGNC Symbol;Acc:HGNC:25667] |
| Ensembl ID | ENSG00000120280 |
| Bio databases IDs | |
| Aliases | TLR adaptor interacting with endolysosomal SLC15A4, TLR adaptor interacting with SLC15A4 on the lysosome |
| Synonyms | 5430427O19Rik, CXorf21, RGD1565785, TLR adaptor interacting with endolysosomal SLC15A4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TASL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TLR adaptor interacting with SLC15A4 on the lysosome
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- lysosome membrane
- endosomal membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TASL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of toll-like receptor 8 signaling pathway
- regulation of lysosomal lumen pH
- positive regulation of innate immune response
- innate immune response
- regulation of toll-like receptor signaling pathway
- positive regulation of toll-like receptor 7 signaling pathway
Cellular Component
Where in the cell the gene product is active
- endolysosome membrane
- intracellular membrane-bounded organelle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding