IFIT2 Gene Summary [Human]
Enables RNA binding activity. Involved in negative regulation of protein binding activity; positive regulation of apoptotic process; and response to virus. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | IFIT2 |
| Official Name | interferon induced protein with tetratricopeptide repeats 2 [Source:HGNC Symbol;Acc:HGNC:5409] |
| Ensembl ID | ENSG00000119922 |
| Bio databases IDs | |
| Aliases | interferon induced protein with tetratricopeptide repeats 2 |
| Synonyms | cig42, G10P2, GARG-39, IFI-54, IFI-54K, interferon-induced protein with tetratricopeptide repeats 2, ISG-54, ISG-54 K, ISGF54 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IFIT2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- type IV pilus biogenesis/stability protein PilW
- protein binding
- tetratricopeptide repeat
Pathways
Biological processes and signaling networks where the IFIT2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- plasma cell myeloma
- insulin-dependent diabetes mellitus
- paralysis
- systemic lupus erythematosus
- encephalitis
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- COVID-19
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- diabetes mellitus
- neonatal late-onset sepsis
role in cell
- expression in
- activation in
- migration
- proliferation
- apoptosis
- phosphorylation in
- production in
- activation
- binding in
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IFIT2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic mitochondrial changes
- positive regulation of apoptotic process
- defense response to virus
- response to virus
- negative regulation of protein binding
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding