IGSF1 Gene Summary [Human]
This gene encodes a member of the immunoglobulin-like domain-containing superfamily. Proteins in this superfamily contain varying numbers of immunoglobulin-like domains and are thought to participate in the regulation of interactions between cells. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
Details
| Type | Protein Coding |
| Official Symbol | IGSF1 |
| Official Name | immunoglobulin superfamily member 1 [Source:HGNC Symbol;Acc:HGNC:5948] |
| Ensembl ID | ENSG00000147255 |
| Bio databases IDs | |
| Aliases | immunoglobulin superfamily member 1 |
| Synonyms | 5330413N23, 5530402E03, CHTE, IGCD1, IGDC1, immunoglobulin superfamily member 1, immunoglobulin superfamily, member 1, INHBP, InhBP/p120, mKIAA0364, p120, PGSF2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IGSF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- receptor antagonist activity
- immunoglobulin domain
- Immunoglobulin like
- protein binding
- coreceptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- central hypothyroidism and testicular enlargement
- insomnia
- hereditary disorder
- weight gain
- Huntington disease
- thyroid carcinoma
- epithelial thyroid cancer
- heart failure
role in cell
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IGSF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response-regulating signaling pathway
- negative regulation of activin receptor signaling pathway
- regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- activin receptor antagonist activity
- protein binding
- inhibin binding