BCL2L14 Gene Summary [Human]
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported for this gene. [provided by RefSeq, May 2009]
Details
| Type | Protein Coding |
| Official Symbol | BCL2L14 |
| Official Name | BCL2 like 14 [Source:HGNC Symbol;Acc:HGNC:16657] |
| Ensembl ID | ENSG00000121380 |
| Bio databases IDs | |
| Aliases | BCL2 like 14 |
| Synonyms | 4930452K23Rik, 4933405K19Rik, 9030625M01Rik, BCL2 like 14, BCLG, LOC101928224, LOC102724106 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BCL2L14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Bcl-2_like
- protein kinase binding
- Bcl-2 homology 2 domain
- Bcl-2 homology 3 domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- diabetes mellitus
- systemic lupus erythematosus
- COVID-19
- lung adenocarcinoma
- lung adenocarcinoma formation
- pemphigus foliaceus
- male pattern hair loss
role in cell
- apoptosis
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- organelle
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BCL2L14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process
- regulation of extrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- intracellular organelle
- membrane
- cytosol
- endomembrane system
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding