Cd244a Gene Summary [Mouse]
Predicted to enable MHC class I protein binding activity. Involved in myeloid dendritic cell activation; natural killer cell activation involved in immune response; and positive regulation of lymphocyte proliferation. Located in external side of plasma membrane. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Orthologous to human CD244 (CD244 molecule). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd244a |
| Official Name | CD244 molecule A [Source:MGI Symbol;Acc:MGI:109294] |
| Ensembl ID | ENSMUSG00000004709 |
| Bio databases IDs | |
| Aliases | CD244 molecule A |
| Synonyms | 2B4, C9.1, Cd244a, CD244 antigen, CD244 molecule, CD244 molecule A, F730046O15Rik, h2B4, Ly90, NAIL, NKR2B4, NMRK, SLAMF4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd244a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- soluble domain
- MHC class I protein binding
- signaling receptor activity
- immunoglobulin domain
- protein binding
- V domain
- cytoplasmic domain
- cytosolic tail domain
- tyrosine phosphorylation site
- Immunoglobulin V-set domain
- transmembrane receptor
- immunoreceptor tyrosine switch motif
- tyrosine-based motif
Pathways
Biological processes and signaling networks where the Cd244a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- susceptibility to rheumatoid arthritis
- diabetic nephropathy
- cutaneous melanoma
- cutaneous melanoma cancer
- Crohn disease
- intrauterine growth retardation
- chronic lymphocytic leukemia
role in cell
- expression in
- quantity
- proliferation
- activation
- activation in
- production in
- activity
- phosphorylation in
- binding in
- cytotoxicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd244a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- natural killer cell activation involved in immune response
- positive regulation of interleukin-8 production
- positive regulation of granzyme B production
- signal transduction
- innate immune response
- positive regulation of interferon-gamma production
- adaptive immune response
- positive regulation of inositol phosphate biosynthetic process
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity
- MHC class I protein binding