IL13RA1 Gene Summary [Human]
The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IL13RA1 |
| Official Name | interleukin 13 receptor subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:5974] |
| Ensembl ID | ENSG00000131724 |
| Bio databases IDs | |
| Aliases | interleukin 13 receptor subunit alpha 1, IL13 receptor alpha-1 chain, CD213a1 antigen |
| Synonyms | CD213A1, CT19, IL-13Ra, IL-13r[a], IL13R alpha', IL13R-alpha, IL-13R-alpha-1, IL13 receptor alpha1, IL13R α', IL13R-α, IL-13R-α-1, interleukin 13 receptor, alpha 1, interleukin 13 receptor subunit alpha 1, interleukin 13 receptor subunit α 1, interleukin 13 receptor, α 1, Interleukin 13 receptor α 1 chain, NR4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL13RA1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Interleukin-13 receptor subunit alpha Ig-like domain
- FN3
- transmembrane domain
- protein binding
- proline rich domain
- transmembrane receptor
- interleukin-13 receptor
Pathways
Biological processes and signaling networks where the IL13RA1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atopic dermatitis
- sinonasal polyposis
- asthma
- eosinophilic esophagitis
- dyssomnia
- chronic atopic dermatitis
- agitated depression
- chronic rhinosinusitis with nasal polyps
- psoriasis
- prurigo nodularis
role in cell
- binding
- proliferation
- function
- differentiation
- activation in
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL13RA1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytokine-mediated signaling pathway
- positive regulation of cell proliferation
- cell surface receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- interleukin-13 receptor complex
- external side of plasma membrane
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytokine receptor activity
- cytokine binding