BATF3 Gene Summary [Human]
This gene encodes a member of the basic leucine zipper protein family. The encoded protein functions as a transcriptional repressor when heterodimerizing with JUN. The protein may play a role in repression of interleukin-2 and matrix metalloproteinase-1 transcription.[provided by RefSeq, Feb 2009]
Details
| Type | Processed Transcript |
| Official Symbol | BATF3 |
| Official Name | basic leucine zipper ATF-like transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:28915] |
| Ensembl ID | ENSG00000123685 |
| Bio databases IDs | |
| Aliases | basic leucine zipper ATF-like transcription factor 3, Jun dimerization protein 1 |
| Synonyms | 9130211I03Rik, basic leucine zipper ATF-like transcription factor 3, basic leucine zipper transcription factor, ATF-like 3, JDP1, JUNDM1, SNFT |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BATF3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- nucleic acid binding
- Basic region leucine zipper
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- binding protein
- double-stranded DNA binding
- bZIP
- transcription factor activity
- basic region leucin zipper
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- eczema
- diabetes mellitus
- androgenic alopecia
- asthma
- infection by Listeria monocytogenes
- infection by Toxoplasma gondii
role in cell
- invasion
- quantity
- activation
- number
- migration
- differentiation
- generation
- function
- antigen presentation by
- cytolysis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BATF3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- myeloid dendritic cell differentiation
- dendritic cell differentiation
- response to virus
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity