RAB22A Gene Summary [Human]
The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RAB22A |
| Official Name | RAB22A, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9764] |
| Ensembl ID | ENSG00000124209 |
| Bio databases IDs | |
| Aliases | RAB22A, member RAS oncogene family |
| Synonyms | 3732413A17Rik, E130120E14Rik, RAB22, RAB22A, member RAS oncogene family |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAB22A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- GTP binding
- small GTP-binding protein domain
- GDP binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the RAB22A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- expression in
- cell death
- accumulation in
- formation
- fragmentation
- outgrowth
- association
- fragmentation in
- outgrowth in
- association in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- actin cytoskeleton
- Plasma Membrane
- endosomes
- vesicles
- Golgi Apparatus
- endosomal membrane
- recycling endosomes
- early endosomes
- perinuclear vesicles
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAB22A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endosome organization
- intracellular protein transport
- endocytosis
Cellular Component
Where in the cell the gene product is active
- early endosome
- extracellular vesicular exosome
- actin cytoskeleton
- ruffle
- late endosome
- phagocytic vesicle
- endomembrane system
- phagocytic vesicle membrane
- endosome membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- GDP binding