EEF1E1 Gene Summary [Human]
This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | EEF1E1 |
| Official Name | eukaryotic translation elongation factor 1 epsilon 1 [Source:HGNC Symbol;Acc:HGNC:3212] |
| Ensembl ID | ENSG00000124802 |
| Bio databases IDs | |
| Aliases | eukaryotic translation elongation factor 1 epsilon 1, aminoacyl tRNA synthetase complex-interacting multifunctional protein 3, multisynthetase complex auxiliary component p18 |
| Synonyms | 1110003A02Rik, AIMP3, Eef1e, eukaryotic translation elongation factor 1 epsilon 1, eukaryotic translation elongation factor 1 ε 1, P18, p18 tRNA synthetase complex component |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EEF1E1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, C-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- protein binding
- translation regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EEF1E1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA damage response, signal transduction by p53 class mediator
- negative regulation of cell proliferation
- positive regulation of apoptotic process
- positive regulation of cellular senescence
- positive regulation of apoptotic signaling pathway
- translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- aminoacyl-tRNA synthetase multienzyme complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding