Eef1e1 Gene Summary [Mouse]
Involved in negative regulation of cell population proliferation; positive regulation of DNA damage response, signal transduction by p53 class mediator; and positive regulation of apoptotic process. Acts upstream of or within cellular response to leukemia inhibitory factor and positive regulation of apoptotic signaling pathway. Located in cytoplasm and nucleus. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including central nervous system and retina. Orthologous to human EEF1E1 (eukaryotic translation elongation factor 1 epsilon 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eef1e1 |
| Official Name | eukaryotic translation elongation factor 1 epsilon 1 [Source:MGI Symbol;Acc:MGI:1913393] |
| Ensembl ID | ENSMUSG00000001707 |
| Bio databases IDs | |
| Aliases | eukaryotic translation elongation factor 1 epsilon 1 |
| Synonyms | 1110003A02Rik, AIMP3, Eef1e, eukaryotic translation elongation factor 1 epsilon 1, eukaryotic translation elongation factor 1 ε 1, P18, p18 tRNA synthetase complex component |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eef1e1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, C-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- protein binding
- translation regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eef1e1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA damage response, signal transduction by p53 class mediator
- negative regulation of cell proliferation
- positive regulation of apoptotic process
- positive regulation of cellular senescence
- positive regulation of apoptotic signaling pathway
- translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- aminoacyl-tRNA synthetase multienzyme complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding