CDK16 Gene Summary [Human]
The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009]
Details
| Type | Processed Transcript |
| Official Symbol | CDK16 |
| Official Name | cyclin dependent kinase 16 [Source:HGNC Symbol;Acc:HGNC:8749] |
| Ensembl ID | ENSG00000102225 |
| Bio databases IDs | |
| Aliases | cyclin dependent kinase 16, serine/threonine-protein kinase |
| Synonyms | Crk5, cyclin-dependent kinase 16, PCTAIR1, PCTAIRE, PCTAIRE1, PCTGAIRE, PCTK1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDK16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the CDK16 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthenozoospermia
- congenital malformation
- X-linked complex neurodevelopmental disorder
- Klinefelter syndrome
role in cell
- exocytosis by
- binding in
- quantity
- morphogenesis
- thinning
- abnormal morphology
- autophagy by
- thinning in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- synaptosomal membrane fractions
- synaptic vesicle membrane
- microtubule cytoskeleton
- cellular membrane
- Plasma Membrane
- cytosol
- cytoplasmic face of plasma membrane
- synaptic vesicles
- neuromuscular junctions
- sarcolemma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDK16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of insulin secretion involved in cellular response to glucose stimulus
- positive regulation of autophagy
- neuron projection development
- spermatogenesis
- growth hormone secretion
- regulation of cell cycle
- protein phosphorylation
- exocytosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- microtubule cytoskeleton
- cytoplasm
- synaptic vesicle
- cyclin-dependent protein kinase holoenzyme complex
- cytosol
- neuron projection
- plasma membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- cyclin-dependent protein kinase activity
- protein serine/threonine kinase activity