SRMS Gene Summary [Human]
Enables protein tyrosine kinase activity. Involved in peptidyl-tyrosine autophosphorylation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SRMS |
| Official Name | src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites [Source:HGNC Symbol;Acc:HGNC:11298] |
| Ensembl ID | ENSG00000125508 |
| Bio databases IDs | |
| Aliases | src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites |
| Synonyms | A230069J08Rik, C20orf148, dJ697K14.1, PTK70, src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites, SRM |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SRMS often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- Src homology 2 (SH2) domain
- protein binding
- Protein kinase domain
- protein-tyrosine kinase
- Tyrosine kinase, catalytic domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the SRMS gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- metastasis
- cutaneous melanoma
- metastatic cutaneous melanoma
- metastatic follicular thyroid carcinoma
- metastatic melanoma
- Langerhans cell histiocytosis of lung
- thyroid oncocytic carcinoma
- melanoma
regulated by
- hydrogen peroxide
- Trolox C
- cisplatin
- ibrutinib
- Hel
- IgG1
- IgM
- PLX 4720
- vemurafenib
- selumetinib
role in cell
- expression in
- apoptosis
- growth
- autophagy in
- phosphorylation in
- binding in
- transactivation in
- cisplatin sensitivity
- tyrosine phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SRMS gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine phosphorylation
- negative regulation of signal transduction
- innate immune response
- cell differentiation
- transmembrane receptor protein tyrosine kinase signaling pathway
- peptidyl-tyrosine autophosphorylation
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein binding
- non-membrane spanning protein tyrosine kinase activity
- receptor binding