PSD4
PSD4 Gene Summary
Predicted to enable guanyl-nucleotide exchange factor activity and phospholipid binding activity. Predicted to be involved in regulation of ARF protein signal transduction and regulation of catalytic activity. Located in ruffle membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | PSD4 |
| Official Name | pleckstrin and Sec7 domain containing 4 [Source:HGNC Symbol;Acc:HGNC:19096] |
| Ensembl ID | ENSG00000125637 |
| Bio databases IDs | |
| Aliases | pleckstrin and Sec7 domain containing 4 |
| Synonyms | EFA6B,pleckstrin and Sec7 domain containing 4,Sec7,TIC |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sec7
- Sec7 domain
- PH domain
- protein binding
- Pleckstrin homology-like domain
Pathways
Biological processes and signaling networks where the PSD4 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- HRAS
- USP9X
- LDLRAP1
- ZRANB1
- SNX17
- YWHAZ
- ARF6
- THNSL1
- ACAD11
- ATG16L1
disease
- colorectal carcinoma
- colorectal carcinomagenesis
- disorder of testis
regulated by
- neutrophils
- dexamethasone
- EHMT1
- FAS
- MYB family
- camptothecin
- ESR1
regulates
role in cell
- epithelial-mesenchymal transition
- apico-basal polarity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- apical compartment
- membrane ruffles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PSD4 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- regulation of ARF protein signal transduction
CELLULAR COMPONENT
Where in the cell the gene product is active
- cleavage furrow
- membrane
- ruffle membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- guanyl-nucleotide exchange factor activity
- phospholipid binding