DTD1 Gene Summary [Human]
The protein encoded by this gene is similar in sequence to histidyl-tRNA synthetase, which hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). The encoded protein binds the DNA unwinding element and plays a role in the initiation of DNA replication. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | DTD1 |
| Official Name | D-aminoacyl-tRNA deacylase 1 [Source:HGNC Symbol;Acc:HGNC:16219] |
| Ensembl ID | ENSG00000125821 |
| Bio databases IDs | |
| Aliases | D-aminoacyl-tRNA deacylase 1, DNA-unwinding element-binding protein B |
| Synonyms | 0610006H08Rik, C20orf88, D-aminoacyl-tRNA deacylase 1, DTD, D-tyrosyl-tRNA deacylase 1, DUE-B, HARS2, pqn-68 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DTD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- D-Tyr-tRNA(Tyr) deacylase
- Dtyr_deacylase
- enzyme
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DTD1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA duplex unwinding
- DNA replication
- tRNA metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- D-tyrosyl-tRNA(Tyr) deacylase activity
- DNA binding
- metal ion binding
- tRNA binding