POLK
POLK Gene Summary
This gene encodes a member of the DNA polymerase type-Y family of proteins. The encoded protein is a specialized DNA polymerase that catalyzes translesion DNA synthesis, which allows DNA replication in the presence of DNA lesions. Human cell lines lacking a functional copy of this gene exhibit impaired genome integrity and enhanced susceptibility to oxidative damage. Mutations in this gene that impair enzyme activity may be associated with prostate cancer in human patients. [provided by RefSeq, Sep 2016]
Details
| Type | Protein Coding |
| Official Symbol | POLK |
| Official Name | DNA polymerase kappa [Source:HGNC Symbol;Acc:HGNC:9183] |
| Ensembl ID | ENSG00000122008 |
| Bio databases IDs | |
| Aliases | DNA polymerase kappa, DINB protein |
| Synonyms | DINB1,DINP,DNA Polkappa,DNA polymerase kappa,DNA polymerase κ,DNA Polκ,POLQ,polymerase (DNA directed), kappa,polymerase (DNA directed), κ |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IMS family HHH motif
- DNA-directed DNA polymerase
- Rad18-like CCHC zinc finger
- ubiquitin binding domain
- impB/mucB/samB family C-terminal domain
- enzyme
- protein binding
- impB/mucB/samB family
- Y-family of DNA polymerases
Pathways
Biological processes and signaling networks where the POLK gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ITCH
- REV1
- KCTD2
- RAD51
- TP53
- XRCC1
- POLD1
- PCGF5
- MAK16
- APOL2
disease
- familial prostate cancer
- non-insulin-dependent diabetes mellitus
regulated by
- ERBB2
- rebemadlin
- TP53
- epigallocatechin-gallate
- cantharidin
- WRN
- MSH3
- 7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
- PCNA
- REV1
regulates
- CHEK1
- ATM
- CHEK2
- H2AX
role in cell
- phosphorylation in
- proliferation
- synthesis in
- cell death
- survival
- colony formation by
- mutagenesis
- S phase
- DNA damage response
- sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the POLK gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- DNA repair
- DNA replication
- cellular response to UV
- error-prone translesion synthesis
- nucleotide-excision repair, DNA gap filling
- response to DNA damage stimulus
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- nuclear body
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- DNA-directed DNA polymerase activity
- metal ion binding
- damaged DNA binding