KIRREL2 Gene Summary [Human]
This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules. The encoded protein localizes to adherens junctions in pancreatic beta cells and regulates insulin secretion. Autoantibodies against the encoded protein have been detected in serum from patients with type 1 diabetes. This gene may also play a role in glomerular development and decreased expression of this gene has been observed in human glomerular diseases. This gene and the related opposite-strand gene nephrin (GeneID: 527362) are regulated by a bidirectional promoter. [provided by RefSeq, Jul 2016]
Details
| Type | Protein Coding |
| Official Symbol | KIRREL2 |
| Official Name | kirre like nephrin family adhesion molecule 2 [Source:HGNC Symbol;Acc:HGNC:18816] |
| Ensembl ID | ENSG00000126259 |
| Bio databases IDs | |
| Aliases | kirre like nephrin family adhesion molecule 2 |
| Synonyms | C330019F22Rik, FILTRIN, kirre like nephrin family adhesion molecule 2, NEPH3, NLG1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KIRREL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PKD domain
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- Cadherin repeat-like domain
- protein binding
- identical protein binding
- Immunoglobulin V-set domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- intercellular junctions
- cell-cell contacts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KIRREL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein phosphorylation
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- slit diaphragm
- cell-cell junction
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- cell adhesion molecule binding