WNK3 Gene Summary [Human]
This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | WNK3 |
| Official Name | WNK lysine deficient protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:14543] |
| Ensembl ID | ENSG00000196632 |
| Bio databases IDs | |
| Aliases | WNK lysine deficient protein kinase 3 |
| Synonyms | LOC279561, MRXS2, PRKWNK3, PRS, RGD1563131, Wnk3-ps, WNK lysine deficient protein kinase 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WNK3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding activity, bridging
- ATP binding
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- ion channel binding
- Oxidative-stress-responsive kinase 1 C-terminal domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Prieto X-linked mental retardation syndrome
- neurodevelopmental disorder
- Alzheimer disease
role in cell
- expression in
- apoptosis
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- tight junctions
- membrane processes
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WNK3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- osmosensory signaling pathway
- regulation of calcium ion import
- negative regulation of pancreatic juice secretion
- positive regulation of calcium ion transport
- protein autophosphorylation
- protein phosphorylation
- cell volume homeostasis
- negative regulation of apoptotic process
- cellular hyperosmotic response
- positive regulation of sodium ion transport
- positive regulation of peptidyl-threonine phosphorylation
- ion homeostasis
- positive regulation of ion transmembrane transporter activity
- protein localization in plasma membrane
- positive regulation of sodium ion transmembrane transporter activity
- maintenance of blood-brain barrier
- peptidyl-threonine phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- adherens junction
- tight junction
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein kinase activity
- protein serine/threonine kinase activity