PIK3C3 Gene Summary [Human]
Enables 1-phosphatidylinositol-3-kinase activity. Involved in early endosome to late endosome transport and regulation of cytokinesis. Acts upstream of or within autophagy and protein lipidation. Located in autolysosome; late endosome; and midbody. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PIK3C3 |
| Official Name | phosphatidylinositol 3-kinase catalytic subunit type 3 [Source:HGNC Symbol;Acc:HGNC:8974] |
| Ensembl ID | ENSG00000078142 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol 3-kinase catalytic subunit type 3, vacuolar protein sorting 34 homolog |
| Synonyms | 5330434F23RIK, hVps34, phosphatidylinositol 3-kinase catalytic subunit type 3, phosphatidylinositol 3-kinase, catalytic subunit type 3, PI3KC3, VPS34 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PIK3C3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation domain
- lipid kinase
- protein kinase
- Phosphatidylinositol 3- and 4-kinase
- coiled-coil domain
- protein binding
- PI3Ka
- kinase
- phosphatidylinositol 3-kinase
- Phosphoinositide 3-kinase, catalytic domain
- Protein Kinases, catalytic domain
- alcohol group acceptor phosphotransferase
- C2 domain
Pathways
Biological processes and signaling networks where the PIK3C3 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Apelin Cardiomyocyte Signaling Pathway
- Apelin Pancreas Signaling Pathway
- Clathrin-mediated Endocytosis Signaling
- CNTF Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- ErbB Signaling
- ErbB4 Signaling
- Glucocorticoid Receptor Signaling
- Growth Hormone Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-9 Signaling
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- Mouse Embryonic Stem Cell Pluripotency
- MSP-RON Signaling Pathway
- Neurotrophin/TRK Signaling
- NGF Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- p53 Signaling
- PDGF Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Th1 Pathway
- Th2 Pathway
- Thyroid Cancer Signaling
- UVA-Induced MAPK Signaling
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- metastasis
- anemia
- peripheral T-cell lymphoma
- natural killer/T-cell lymphoma
- weight loss
- growth failure
- metabolic syndrome X
- T-cell non-Hodgkin disease
- natural killer cell neoplasia
role in cell
- expression in
- apoptosis
- growth
- activation in
- size
- quantity
- autophagy in
- proliferation
- cell death
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- endosomes
- axonemes
- midbody
- cytosol
- synapse
- early endosomes
- late endosomes
- multivesicular bodies
- autolysosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PIK3C3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization to pre-autophagosomal structure
- phosphatidylinositol-3-phosphate biosynthetic process
- protein lipidation
- phosphatidylinositol phosphorylation
- endocytosis
- protein targeting to lysosome
- cellular response to glucose starvation
- cell division
- autophagic vacuole assembly
- phosphatidylinositol-mediated signaling
- autophagy
- early endosome to late endosome transport
- regulation of autophagy
- peroxisome degradation
- regulation of cytokinesis
- regulation of macroautophagy
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- phosphatidylinositol 3-kinase complex II
- phosphatidylinositol 3-kinase complex I
- pre-autophagosomal structure
- phosphatidylinositol 3-kinase complex, class III
- late endosome
- axoneme
- autophagic vacuole
- peroxisome
- endosome
- cytoplasm
- membrane
- phagocytic vesicle membrane
- cytosol
- midbody
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol kinase activity
- ATP binding
- protein binding
- protein kinase activity
- kinase activity
- 1-phosphatidylinositol-3-kinase activity