DYRK2 Gene Summary [Human]
DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | DYRK2 |
| Official Name | dual specificity tyrosine phosphorylation regulated kinase 2 [Source:HGNC Symbol;Acc:HGNC:3093] |
| Ensembl ID | ENSG00000127334 |
| Bio databases IDs | |
| Aliases | dual specificity tyrosine phosphorylation regulated kinase 2 |
| Synonyms | 1810038L18RIK, DUAL-SPECIFICITY TYROSINE PHOSPHORYLATION-REGULATED KINASE 2, Dyrk2 predicted |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DYRK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein threonine/tyrosine kinase
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- protein-tyrosine kinase
- magnesium ion binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- ATP-binding pocket
- Protein Kinases, catalytic domain
- manganese ion binding
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the DYRK2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- uterine leiomyoma
- systemic autoimmune syndrome
- leiomyomatosis
- immunodeficiency
role in cell
- proliferation
- expression in
- activation in
- phosphorylation in
- ploidy
- binding in
- downregulation in
- polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DYRK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of calcineurin-NFAT signaling cascade
- DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
- smoothened signaling pathway
- protein phosphorylation
- response to DNA damage stimulus
- peptidyl-serine phosphorylation
- positive regulation of glycogen biosynthetic process
- peptidyl-threonine phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- ubiquitin ligase complex
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein tyrosine kinase activity
- protein serine/threonine/tyrosine kinase activity
- protein binding
- manganese ion binding
- protein serine/threonine kinase activity