AAMP Gene Summary [Human]
The gene is a member of the immunoglobulin superfamily. The encoded protein is associated with angiogenesis, with potential roles in endothelial tube formation and the migration of endothelial cells. It may also regulate smooth muscle cell migration via the RhoA pathway. The encoded protein can bind to heparin and may mediate heparin-sensitive cell adhesion. [provided by RefSeq, Oct 2014]
Details
| Type | Protein Coding |
| Official Symbol | AAMP |
| Official Name | angio associated migratory cell protein [Source:HGNC Symbol;Acc:HGNC:18] |
| Ensembl ID | ENSG00000127837 |
| Bio databases IDs | |
| Aliases | angio associated migratory cell protein |
| Synonyms | Aamp-rs, angio associated migratory cell protein, angio-associated, migratory cell protein, angio-associated migratory protein |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AAMP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Anaphase-promoting complex subunit 4 WD40 domain
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
- heparin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microtubule cytoskeleton
- cell surface
- cytoplasmic bridges
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AAMP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- smooth muscle cell migration
- angiogenesis
- cell differentiation
- positive regulation of endothelial cell migration
Cellular Component
Where in the cell the gene product is active
- intercellular bridge
- microtubule cytoskeleton
- cytosol
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- heparin binding