MARCHF3 Gene Summary [Human]
This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. [provided by RefSeq, Mar 2013]
Details
| Type | Protein Coding |
| Official Symbol | MARCHF3 |
| Official Name | membrane associated ring-CH-type finger 3 [Source:HGNC Symbol;Acc:HGNC:28728] |
| Ensembl ID | ENSG00000173926 |
| Bio databases IDs | |
| Aliases | membrane associated ring-CH-type finger 3 |
| Synonyms | 6330411I15RIK, A530081L18RIK, AI843639, LOC153277, MARCH3, MARCH-III, membrane associated ring-CH-type finger 3, MGC48332, RNF173 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MARCHF3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hepatocellular carcinoma
- non-insulin-dependent diabetes mellitus
- liver cancer
- overall survival
- latent tuberculosis
role in cell
- expression in
- phosphorylation in
- activation in
- proliferation
- invasion by
- migration
- differentiation
- transcription in
- degradation in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- endosomes
- lysosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MARCHF3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endocytosis
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- endosome
- intracellular membrane-bounded organelle
- lysosome
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- protein binding