LSM8

LSM8 Gene Summary

This gene encodes a member of the like-Sm family of proteins. The encoded protein consists of a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. This protein partners with six paralogs to form a heteroheptameric ring which transiently binds U6 small nuclear RNAs and is involved in the general maturation of RNA in the nucleus. [provided by RefSeq, Jan 2010]

Details

Type
Protein Coding
Official Symbol
LSM8
Official Name
LSM8 homolog, U6 small nuclear RNA associated [Source:HGNC Symbol;Acc:HGNC:20471]
Ensembl ID
ENSG00000128534
Bio databases IDs NCBI: 51691 Ensembl: ENSG00000128534
Aliases LSM8 homolog, U6 small nuclear RNA associated
Synonyms
2010003I05Rik,LSM8 homolog, U6 small nuclear RNA associated,NAA38
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Sm and related proteins
  • protein binding

Pathways

Biological processes and signaling networks where the LSM8 gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • PDCD2
  • SNRPF
  • CCNF
  • LSM6
  • EXOSC10
  • PRPF8
  • DCTN1
  • SART3
  • GTF2I
  • MAPK8IP2
disease
regulated by
  • Dlx6os1
  • ACHE
  • LOC100912227
  • CEBPB
  • Major late
regulates
role in cell
  • cell viability
  • splicing by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • spliceosomes
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the LSM8 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • nuclear mRNA splicing, via spliceosome

CELLULAR COMPONENT

Where in the cell the gene product is active
  • nucleus
  • precatalytic spliceosome
  • U4/U6 x U5 tri-snRNP complex
  • U2-type precatalytic spliceosome
  • U6 snRNP
  • nucleoplasm

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • U6 snRNA binding
  • RNA binding
  • protein binding
  • mRNA binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.