PDCD2 Gene Summary [Human]
This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12. [provided by RefSeq, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | PDCD2 |
| Official Name | programmed cell death 2 [Source:HGNC Symbol;Acc:HGNC:8762] |
| Ensembl ID | ENSG00000071994 |
| Bio databases IDs | |
| Aliases | programmed cell death 2 |
| Synonyms | Pcd2, programmed cell death 2, RP-8, ZMYND7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PDCD2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Programmed cell death protein 2, C-terminal putative domain
- MYND finger
- enzyme binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sporadic Parkinson disease
- autosomal recessive Parkinson disease
- chronic fatigue syndrome
- growth failure
- infection by Influenza A virus subtype H1N1
role in cell
- apoptosis
- proliferation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PDCD2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process
- positive regulation of apoptotic process
- activation of cysteine-type endopeptidase activity involved in apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding
- enzyme binding