SART3 Gene Summary [Human]
The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SART3 |
| Official Name | spliceosome associated factor 3, U4/U6 recycling protein [Source:HGNC Symbol;Acc:HGNC:16860] |
| Ensembl ID | ENSG00000075856 |
| Bio databases IDs | |
| Aliases | spliceosome associated factor 3, U4/U6 recycling protein, HIV-1 Tat-interacting protein of 110kDa, PRP24 homolog |
| Synonyms | DSAP1, mKIAA0156, P100, p110(nrb), RP11-13G14, spliceosome associated factor 3, U4/U6 recycling protein, squamous cell carcinoma antigen recognized by T cells 3, TIP110 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SART3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HAT (Half-A-TPR) repeats
- histone binding
- histone acetyltransferase domain
- RNA recognition motif (RRM) superfamily
- LXXLL motif
- U4 snRNA binding
- U6atac snRNA binding
- protease binding
- RNA recognition motif
- U6 snRNA binding
- protein binding activity, bridging
- nuclear localization sequence
- Occluded RNA-recognition motif
- protein binding
- RNA binding
- LSM-interacting associated unstructured
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- open-angle glaucoma
role in cell
- cell viability
- proliferation
- morphogenesis
- growth
- splicing by
- assembly
- tumorigenicity
- G1 phase
- JQ1 resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- Cajal bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SART3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell morphogenesis
- homeostasis of number of cells
- regulation of gene expression
- hemopoietic stem cell proliferation
- nucleosome assembly
- spliceosomal snRNP assembly
- nuclear mRNA splicing, via spliceosome
- assembly of spliceosomal tri-snRNP
Cellular Component
Where in the cell the gene product is active
- nucleus
- U4atac/U6atac snRNP
- cytoplasm
- nuclear speck
- U6atac snRNP
- U4/U6 x U5 tri-snRNP complex
- U4/U6 snRNP
- Cajal body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- U6atac snRNA binding
- U6 snRNA binding
- protein binding
- RNA binding
- histone binding
- U4 snRNA binding