ZBTB7B Gene Summary [Human]
This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Details
| Type | Protein Coding |
| Official Symbol | ZBTB7B |
| Official Name | zinc finger and BTB domain containing 7B [Source:HGNC Symbol;Acc:HGNC:18668] |
| Ensembl ID | ENSG00000160685 |
| Bio databases IDs | |
| Aliases | zinc finger and BTB domain containing 7B, zinc finger and BTB domain containing 15 |
| Synonyms | C2H2-Type Domain Containing, CKROX, hcKROX, THPOK, vGAF, ZBTB15, ZFP-67, zinc finger and BTB domain containing 7B, ZNF857B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZBTB7B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- BTB_POZ
- histone deacetylase binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- GAGA factor
- zinc finger
- double-stranded DNA binding
- Broad-Complex, Tramtrack and Bric a brac
- Zinc-finger double domain
- protein homodimerization
- BTB/POZ domain
- zinc finger domain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- epithelial cancer
- adenoma formation
- schizophrenia
- atrial fibrillation
- microadenoma
- prostatic carcinoma
- prostate cancer
- colorectal carcinoma
role in cell
- transcription in
- formation
- acetylation in
- expression in
- proliferation
- quantity
- degradation in
- differentiation
- production in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZBTB7B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of insulin receptor signaling pathway
- positive regulation of brown fat cell differentiation
- transcription from RNA polymerase II promoter
- lactation
- ectoderm development
- negative regulation of CD8-positive, alpha-beta T cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression
- response to insulin stimulus
- positive regulation of CD4-positive, alpha-beta T cell differentiation
- NK T cell differentiation
- negative regulation of NK T cell proliferation
- positive regulation of gene expression
- positive regulation of interleukin-17 production
- negative regulation of T-helper 17 cell differentiation
- positive regulation of SREBP-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- histone deacetylase binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity