INO80 Gene Summary [Human]
This gene encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the INO80 chromatin remodeling complex, which is characterized by a DNA-binding domain. This protein is proposed to bind DNA and be recruited by the YY1 transcription factor to activate certain genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Details
| Type | Protein Coding |
| Official Symbol | INO80 |
| Official Name | INO80 complex ATPase subunit [Source:HGNC Symbol;Acc:HGNC:26956] |
| Ensembl ID | ENSG00000128908 |
| Bio databases IDs | |
| Aliases | INO80 complex ATPase subunit, INO80 complex subunit A |
| Synonyms | 2310079N15Rik, 4632409L19Rik, INO80A, INO80 complex ATPase subunit, INO80 complex subunit, INOC1, RGD1310969 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human INO80 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha-tubulin binding
- SNF2-related domain
- helicase superfamily c-terminal domain
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DNA-binding domain
- enzyme
- protein binding
- DEAD-like helicases superfamily
- DNA dependent ATPase
- Helicase conserved C-terminal domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hematological neoplasia
- cancer
- lymphomagenesis
- non-Hodgkin disease
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- hematologic cancer
- growth failure
- liver cancer
- lymphoid cancer
regulates
- DNA endogenous promoter
- DNA promoter
- RNA polymerase II
role in cell
- growth
- maintenance
- organization
- cell cycle progression
- response by
- assembly
- remodeling
- segregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nuclear bodies
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human INO80 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- regulation of DNA strand elongation
- regulation of chromosome organization
- regulation of DNA repair
- positive regulation of transcription from RNA polymerase II promoter
- double-strand break repair
- cell division
- spindle assembly
- chromatin remodeling
- positive regulation of cell growth
- positive regulation of transcription, DNA-dependent
- cellular response to UV
- cellular response to ionizing radiation
- regulation of cell cycle
- positive regulation of DNA repair
- UV-damage excision repair
- positive regulation of DNA replication involved in S phase
- transcription, DNA-dependent
- double-strand break repair via homologous recombination
- regulation of embryonic development
- telomere maintenance
- regulation of DNA replication
- mitotic sister chromatid segregation
- regulation of G1/S transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- spindle
- cytosol
- Ino80 complex
- nucleoplasm
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- DNA binding
- ATP binding
- DNA-dependent ATPase activity
- protein binding
- actin binding
- histone binding
- alpha-tubulin binding