DCTD Gene Summary [Human]
The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | DCTD |
| Official Name | dCMP deaminase [Source:HGNC Symbol;Acc:HGNC:2710] |
| Ensembl ID | ENSG00000129187 |
| Bio databases IDs | |
| Aliases | dCMP deaminase |
| Synonyms | 6030466N05Rik, dCMP deaminase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DCTD often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytidine_deaminase-like
- MafB19-like deaminase
- Cytidine and deoxycytidylate deaminase zinc-binding region
- N-glycosyl glycosylase
- enzyme
- protein binding
- identical protein binding
- dCMP deaminase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DCTD gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleoside salvage
- nucleotide biosynthetic process
- cytidine deamination
- pyrimidine nucleotide metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- zinc ion binding
- protein binding
- deoxyribonucleoside 5'-monophosphate N-glycosidase activity
- dCMP deaminase activity