FOXJ1 Gene Summary [Human]
This gene encodes a member of the forkhead family of transcription factors. Similar genes in zebrafish and mouse have been shown to regulate the transcription of genes that control the production of motile cilia. The mouse ortholog also functions in the determination of left-right asymmetry. Polymorphisms in this gene are associated with systemic lupus erythematosus and allergic rhinitis.[provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | FOXJ1 |
| Official Name | forkhead box J1 [Source:HGNC Symbol;Acc:HGNC:3816] |
| Ensembl ID | ENSG00000129654 |
| Bio databases IDs | |
| Aliases | forkhead box J1 |
| Synonyms | CILD43, FKHL-13, forkhead box J1, HFH-4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FOXJ1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- FH_FOX
- nucleic acid binding
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- Forkhead domain
- FORKHEAD
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- situs inversus
- primary ciliary dyskinesia type 43
- yolk sac neoplasm
- germ cell neoplasia
- growth failure
- communicating hydrocephalus
- hypoplasia
- congenital heart disease
- primary ciliary dyskinesia type 43 without situs inversus
role in cell
- differentiation
- production in
- activation
- maturation
- expression in
- activation in
- proliferation
- migration
- number
- lack
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FOXJ1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of T cell differentiation in thymus
- establishment of apical/basal cell polarity
- microtubule basal body organization
- protein localization
- lung epithelium development
- axoneme assembly
- epithelium development
- positive regulation of transcription from RNA polymerase II promoter
- motile cilium assembly
- negative regulation of transcription from RNA polymerase II promoter
- heart development
- positive regulation of central B cell tolerance induction
- negative regulation of germinal center formation
- humoral immune response
- cilium morphogenesis
- negative regulation of NF-kappaB transcription factor activity
- spermatogenesis
- pattern specification process
- cell maturation
- brain development
- determination of left/right symmetry
- regulation of transcription from RNA polymerase II promoter
- negative regulation of interleukin-6 production
- negative regulation of T cell proliferation
- negative regulation of humoral immune response mediated by circulating immunoglobulin
- negative regulation of B cell activation
- central tolerance induction
- leukocyte migration
- glomerular parietal epithelial cell development
- actin cytoskeleton organization
- metanephric ureteric bud development
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity