NFIB Gene Summary [Human]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription regulator inhibitor activity. Involved in brain development; negative regulation of DNA binding activity; and regulation of transcription by RNA polymerase II. Located in fibrillar center and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | NFIB |
| Official Name | nuclear factor I B [Source:HGNC Symbol;Acc:HGNC:7785] |
| Ensembl ID | ENSG00000147862 |
| Bio databases IDs | |
| Aliases | nuclear factor I B |
| Synonyms | 6720429L07Rik, CTF, E030026I10RIK, MACID, NF1-B, Nf1-b1, NF-I/B, NFIB3, NFI-RED, Nuclear factor 1/B, nuclear factor I B, nuclear factor I/B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NFIB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- DNA binding domain
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
- N-terminal Mad Homology 1 (MH1) domain
- DNA binding
- Nuclear factor I protein pre-N-terminus
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- MH1 domain
- CTF/NF-I family transcription modulation region
Pathways
Biological processes and signaling networks where the NFIB gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- COVID-19
- Alzheimer disease
- metastasis
- acquired macrocephaly with impaired intellectual development
- hypoplasia
- non-insulin-dependent diabetes mellitus
- schizophrenia
- coronary artery disease
role in cell
- apoptosis
- expression in
- proliferation
- accumulation in
- migration
- formation
- maintenance
- abnormal morphology
- differentiation
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- fibrillar center
- nucleoplasm
- chromatin
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NFIB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Clara cell differentiation
- salivary gland cavitation
- retina development in camera-type eye
- DNA replication
- response to wounding
- chondrocyte differentiation
- positive regulation of transcription from RNA polymerase II promoter
- glandular epithelial cell differentiation
- cell differentiation involved in salivary gland development
- glial cell fate specification
- neuron fate specification
- positive regulation of transcription, DNA-dependent
- hindbrain development
- Type I pneumocyte differentiation
- stem cell proliferation
- regeneration
- exit from mitosis
- commissural neuron axon guidance
- negative regulation of epithelial cell proliferation involved in lung morphogenesis
- stem cell maintenance
- negative regulation of mesenchymal cell proliferation involved in lung development
- cell proliferation in forebrain
- lung ciliated cell differentiation
- brain development
- Type II pneumocyte differentiation
- anterior commissure morphogenesis
- principal sensory nucleus of trigeminal nerve development
- regulation of transcription from RNA polymerase II promoter
- tissue homeostasis
- response to bacterium
- negative regulation of stem cell proliferation
- gene expression
- glial cell proliferation
- glial cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cerebellar mossy fiber
- chromatin
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity