NCAN Gene Summary [Human]
Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and migration.[supplied by OMIM, Jul 2002]
Details
| Type | Protein Coding |
| Official Symbol | NCAN |
| Official Name | neurocan [Source:HGNC Symbol;Acc:HGNC:2465] |
| Ensembl ID | ENSG00000130287 |
| Bio databases IDs | |
| Aliases | neurocan, neurocan proteoglycan |
| Synonyms | C230035B04, CSPG3, CSPG3-RS, LOC100505254, LOC100911345, LOC102550316, NEUR, Neurocan, TGFBIT |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NCAN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCP
- Family of unknown function (DUF5585)
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Link_Domain
- immunoglobulin domain
- Human growth factor-like EGF
- Lectin C-type domain
- Sushi repeat (SCR repeat)
- Extracellular link domain
- Immunoglobulin V-set domain
- SUSHI repeat
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- survival
- bipolar I disorder
- bipolar disorder
- pelvic organ prolapse
- ulcerative colitis
- bipolar II disorder
- inflammatory bowel disease
- coronary disease
regulates
- HDL
- LDL
role in cell
- growth
- number
- function
- adhesion
- formation
- long-term potentiation
- stabilization
- size
- stabilization in
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- soluble fraction
- Golgi lumen
- glutaminergic synapse
- cell surface
- Plasma Membrane
- lysosomal compartment
- synapse
- extracellular matrix
- perikaryon
- perineuronal net
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NCAN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal system development
- central nervous system development
- positive regulation of neuroblast proliferation
- cell adhesion
- glial cell differentiation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- lysosomal lumen
- perineuronal net
- synapse
- extracellular region
- Golgi lumen
Molecular Function
What the gene product does at the molecular level
- calcium ion binding
- hyaluronic acid binding
- carbohydrate binding