Ncan Gene Summary [Mouse]
Predicted to enable calcium ion binding activity; carbohydrate binding activity; and hyaluronic acid binding activity. Involved in modulation of chemical synaptic transmission and regulation of postsynapse organization. Acts upstream of or within regulation of synapse structural plasticity. Is active in GABA-ergic synapse; glutamatergic synapse; and perisynaptic extracellular matrix. Is expressed in lower jaw; nervous system; and sensory organ. Orthologous to human NCAN (neurocan). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ncan |
| Official Name | neurocan [Source:MGI Symbol;Acc:MGI:104694] |
| Ensembl ID | ENSMUSG00000002341 |
| Bio databases IDs | |
| Aliases | neurocan |
| Synonyms | C230035B04, CSPG3, CSPG3-RS, LOC100505254, LOC100911345, LOC102550316, NEUR, Neurocan, TGFBIT |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ncan often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCP
- Family of unknown function (DUF5585)
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Link_Domain
- immunoglobulin domain
- Human growth factor-like EGF
- Lectin C-type domain
- Sushi repeat (SCR repeat)
- Extracellular link domain
- Immunoglobulin V-set domain
- SUSHI repeat
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- survival
- bipolar I disorder
- bipolar disorder
- pelvic organ prolapse
- ulcerative colitis
- bipolar II disorder
- inflammatory bowel disease
- coronary disease
regulates
- HDL
- LDL
role in cell
- growth
- number
- function
- adhesion
- formation
- long-term potentiation
- stabilization
- size
- stabilization in
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- soluble fraction
- Golgi lumen
- glutaminergic synapse
- cell surface
- Plasma Membrane
- lysosomal compartment
- synapse
- extracellular matrix
- perikaryon
- perineuronal net
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ncan gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal system development
- central nervous system development
- positive regulation of neuroblast proliferation
- cell adhesion
- glial cell differentiation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- lysosomal lumen
- perineuronal net
- synapse
- extracellular region
- Golgi lumen
Molecular Function
What the gene product does at the molecular level
- calcium ion binding
- hyaluronic acid binding
- carbohydrate binding