MAS1 Gene Summary [Human]
This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012]
Details
| Type | Protein Coding |
| Official Symbol | MAS1 |
| Official Name | MAS1 proto-oncogene, G protein-coupled receptor [Source:HGNC Symbol;Acc:HGNC:6899] |
| Ensembl ID | ENSG00000130368 |
| Bio databases IDs | |
| Aliases | MAS1 proto-oncogene, G protein-coupled receptor |
| Synonyms | c-mas, MAS, MAS1 oncogene, MAS1 proto-oncogene, G protein-coupled receptor, MasR, Mas receptor, MGRA |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled peptide receptor
- angiotensin receptor
- peptide binding
- angiotensin type II receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the MAS1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- cancer
- atherosclerosis
- hypertension
- tumorigenesis
- fibrosis
- microalbuminuria
- Huntington disease
- impaired glucose tolerance
- tubulo-interstitial fibrosis
role in cell
- proliferation
- expression in
- phosphorylation in
- activation in
- binding
- migration
- induction
- cellular infiltration by
- tumorigenicity
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein kinase C signaling cascade
- G-protein coupled receptor signaling pathway
- male gonad development
- spermatogenesis
- positive regulation of cell proliferation
- angiotensin-mediated signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- hippocampus development
- positive regulation of DNA replication
- response to xenobiotic stimulus
- positive regulation of inositol phosphate biosynthetic process
- negative regulation of protein phosphorylation
- response to gonadotropin stimulus
- regulation of inflammatory response
- response to activity
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- angiotensin type II receptor activity
- peptide binding
- angiotensin receptor activity